Publications

IL-4 mediated resistance of BALB/c mice to visceral leishmaniasis is independent of IL-4Rα signaling via T cells

McFarlane Emma, Mokgethi Thabang, Kaye Paul M, Hurdayal Ramona, Brombacher Frank, Alexander James, Carter Katharine C

Frontiers in Immunology Vol 10 (2019)

https://doi.org/10.3389/fimmu.2019.01957

Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function

Neamatallah Thikryat, Jabbar Shilan, Tate Rothwelle, Schroeder Juliane, Shweash Muhannad, Alexander James, Plevin Robin

International Journal of Molecular Sciences Vol 20 (2019)

https://doi.org/10.3390/ijms20143434

Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis

Schroeder Juliane, Ross Kirsty, McIntosh Kathryn, Jabbar Shilan Khayrula Jabbar, Woods Stuart, Crowe Jenny, Patterson-Kane Janet C, Alexander James, Lawrence Catherine, Plevin Robin

RMD Open Vol 5, pp. e000711 (2019)

https://doi.org/10.1136/rmdopen-2018-000711

Acanthamoeba proteases contribute to macrophage activation through PAR1, but not PAR2

Cano Antonella, Mattana Antonella, Henriquez Fiona L, Alexander James, Roberts Craig W

Parasite Immunology, pp. e12612 (2018)

https://doi.org/10.1111/pim.12612

Acanthamoeba activates macrophages predominantly through toll-like receptor 4 and MyD88-dependent mechanisms to induce Interleukin IL-12 and IL-6

Cano Antonella, Mattana Antonella, Woods Stuart, Henriquez Fiona L, Alexander James, Roberts Craig W

Infection and Immunity Vol 85 (2017)

https://doi.org/10.1128/IAI.01054-16

Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis

Bobat Saeeda, Darby Matthew, Mrdjen Dunja, Cook Charlotte, Logan Erin, Auret Jennifer, Jones Elizabeth, Schnoeller Corinna, Flores-Langarica Adriana, Ross Ewan A, Vira Alykhan, López-Macías Constantino, Henderson Ian R, Alexander James, Brombacher Frank, Horsnell William G, Cunningham Adam F

PLOS Neglected Tropical Diseases Vol 8 (2014)

https://doi.org/10.1371/journal.pntd.0003341

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Professional Activities

Royal Society (External organisation)

Chair

2008

MRC (External organisation)

Chair

2008

Integrated Functional Genomics on the Road to Leishmaniasis control, UK

Keynote/plenary speaker

1/2008

Infection and Immunity

Editorial board member

2008

International Congresses on Toxoplasmosis , USA

Chair

1/2008

Second Generation Vaccines for Leishmania, WHO, Mexico

Keynote/plenary speaker

1/2008

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Projects

In Vivo Reporting using Nanosystems Chemistry and Optical Spectroscopy

Graham, Duncan (Principal Investigator) Alexander, James (Co-investigator) Brewer, James (Co-investigator) Faulds, Karen (Co-investigator) Garside, Paul (Co-investigator) Maffia, Pasquale (Co-investigator)

The research focus of this feasibility account is in the application of nanoscience into living systems for improvement of health. There are two themes which run through this research focussing on diagnostics and therapeutics. Our existing Platform Grant has allowed us to start looking at functionalised nanoparticles as responsive nanosensors for analysing cell receptors and enzyme activity within cells based on the change in surface enhanced Raman scattering in a number of target systems. The focus so far has been on immunologically compromised cells and, through very exciting preliminary data and discussion with interested, more clinically based parties, we propose to use this feasibility account to allow us to conduct preliminary studies transposing our research to the next level and to that of genuine in vivo experimentation and implementation of nanoscience. So far, the focus has been on diagnostic information retrieval however, here we propose to couple this with a therapeutic aspect. The mounting of biological drugs, such as therapeutic antibodies, onto nanoparticles appears to have significant effect on the efficacy of the drug when used in vitro. To test this in vivo is very challenging and largely an unknown entity. New biological drugs that have been developed are not fully characterised in terms of where they locate within a body and where they provide their most beneficial action. Despite this, FDA approval has been given and we propose to use our combination of nanoscience, spectroscopy functionalisation and immunological/clinical expertise to create a series of cross disciplinary highly adventurous in vivo experiments with a view to pump priming a much larger and consolidated programme of work.

01-Jan-2010 - 31-Jan-2011

Establishment of a biophotonic imaging system for in vivo biology

Brewer, James (Principal Investigator) Alexander, James (Co-investigator) Coombs, Graham (Co-investigator) Garside, Paul (Co-investigator) Lawrence, Catherine (Co-investigator)

01-Jan-2009 - 31-Jan-2014

The cellular basis and pathogenic consequences of mitogen-activated protein kinase phosphatise-2 regulation of innate and adaptive immunity

Plevin, Robin (Principal Investigator) Alexander, James (Co-investigator)

01-Jan-2009 - 31-Jan-2013

The Royal Society International Fellowship - Mr Chesney Michels

Alexander, James (Principal Investigator)

01-Jan-2006 - 31-Jan-2007

Leishmania Macrophage Inhibition Factor activity

Alexander, James (Principal Investigator)

01-Jan-2006 - 29-Jan-2008

OPTICAL SPECTROSCOPIES FOR IMMUNO-BIOMEDICAL APPLICATIONS

Graham, Duncan (Principal Investigator) Alexander, James (Co-investigator) Birch, David (Co-investigator) Faulds, Karen (Co-investigator) Garside, Paul (Co-investigator) Smith, William (Co-investigator)

The manipulation of materials at a molecular level combined with measurement on a scale approaching nanometres means that chemistry can be considered central and enabling to many disciplines such as the life sciences. The ability to produce probes that can be used to report on the biological status of a system at a molecular level is key to advancing the understanding of such systems and how disease and treatments impact on these healthy systems. There is a significant role for chemists to fulfil by providing such ability and this proposal seeks to provide the underlying support to achieve this goal. We have expertise in producing probe molecules that respond to biological stimulus in vitro and can be measured using optical spectroscopies, however, in order for them to be used in vivo new interdisciplinary collaborations need to be established and adventurous experiments attempted to transpose this science out of the test-tube and into the cell.

01-Jan-2006 - 31-Jan-2012

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